Crime lord Adelai Niska hires the crew to rob a train of unspecified goods. The crew is able to transfer the goods to Serenity flying above, but Mal and Zoe Washburne are forced to stay behind on the train. They learn that they have stolen medicine desperately needed by the locals. The crew argue whether they should deliver the goods to Niska. Ultimately, they decide to rescue Mal and Zoe first through subterfuge. Mal decides to return the medicine. However, Niska's thugs track them down. After killing some of them and capturing the rest, Mal and Zoe take the medicine to those in need of it and refund Niska's money.