As Audrey Bayer puts the finishing touches on her husband Greg's 60th birthday party--a milestone Greg is loath to celebrate--cracks begin to emerge in their progressive, multiracial family. Ramone, the couple's Colombian-born son who's just starting a relationship with a barista named Henry, is having unexplained, recurring encounters with the numbers '11:11.' Duc, adopted from Vietnam, enjoys the fruits of a lucrative career as a 'motivational architect,' but his celibacy troubles Audrey. Liberian-born Ashley, a successful fashion-industry exec, is finding more and more reasons to shake up her marriage with her husband Malcolm. And Kristen, the couple's youngest child at 17, chafes at her banal life, especially when compared to those of her more exotic siblings. After a troubling incident at the birthday party, Audrey and Greg take Ramon to a therapist, Dr. Farid Shokrani, who has an unlikely and unexplainable connection to the young man.