Vanessa Bell Calloway began her acting career in the ABC daytime soap opera, All My Children in 1985. After moving to Los Angeles in 1986, she began appearing in episodes of prime time shows such as The Colby's, Falcon Crest, 227, China Beach, A Different World, and L.A. Law. She made her film debut on Number One with a Bullet (1987), had a brief role in the 1988 comedy Coming to America. In 1990, Calloway co-starred in the ABC drama series, Equal Justice. During the 90's, Callowayhad number of supporting roles in films, including What's Love Got to Do with It (1993), The Inkwell (1994), and Crimson Tide (1995). She also voiced main role in the 1992 animated comedy, Bébé's Kids. Calloway also had number of leading and supporting roles in the made for television movies. In 1995, she co-starred in the short-lived CBS prime time soap opera, Under One Roof, the first drama series that feature an African-American lead characters. For her role on the series, Calloway was nominated for the NAACP Image Award for Outstanding Actress in a Drama Series. She also had the leading roles on the short-lived NBC sitcom Rhythm & Blues (1992–93), and starred in the CBS drama Orleans (1997). In 2000, Calloway had the recurring roles on Boston Public and The District. She co-starred in films including The Brothers, All About You, Dawg, Biker Boyz, Love Don't Cost a Thing, and Cheaper by the Dozen. Bell Calloway also guest starred on The Division, Strong Medicine, The Closer, CSI: Crime Scene Investigation, Dexter, Rizzoli & Isles, and Castle. From 2010 to 2011, she had the recurring role in the TNT medical drama, Hawthorne. In 2011, she began appearing in the Showtime comedy-drama, Shameless. In 2016, Bell Calloway was cast as lead character in the Bounce TV first prime time drama series, Saints & Sinners. Also in 2016, Bell Calloway co-starred, in the comedy-drama film Southside with You, which premiered at the 2016 Sundance Film Festival. She also guest starred on the ABC, Grey's Anatomy.