Michael Manning Weatherly, Jr. was born in New York City, to Patricia (Hetherington) and Michael Manning Weatherly, Sr.
Raised in Fairfield, CT, he left college to pursue a career in acting. He also had a great passion for music, and played in a band while pursuing his acting career. He began acting professionally and landed his first job as Theo Huxtable's roommate on The Cosby Show (1984) and a role in the independent film Trigger Happy (2001) opposite Rosario Dawson.
Weatherly married internist Dr. Bojana Jankovic on September 30, 2009. The couple live in Los Angeles with their two children, a daughter, Olivia, and a son, Liam.