Margo Stilley was born in Conway, South Carolina ,is an American actress and writer.she grew up between there and Swansboro, North Carolina.
She moved out of her family home and lived on her own since her 16th birthday. She put herself through high school working as a telemarketer and lifeguard until she graduated a year early from Conway High School (South Carolina) with Honors in Art and History. She was voted "The Funniest" in the class of 2000. Stilley was offered a full scholarship to Savannah College of Art and Design which she declined. It was her interest in art as a platform that shaped her decision to star as Lisa in the controversial 2004 British film 9 Songs, directed by Michael Winterbottom She left the rural South as a teenager to model in Milan with Elite Model Management before moving to London at the age of 18.
Stilley was raised in a strict Baptist household in America's Bible Belt but officially converted to Judaism in 2015 "because of its strong sense of family and of history, and its belief that humans were formed in the image of God and are inherently divine".
In February 2001 Stilley began working briefly as a model in Milan, Italy with Elite Model Management but moved to London by the end of the year to pursue her acting career. Her first acting job was playing Lead actress in the controversial 2004 British film 9 Songs, directed by Michael Winterbottom. According to the Guardian, 9 Songs was the most sexually explicit mainstream film to date, largely because it includes several scenes of real sexual acts between Stilley and her co-star, English actor Kieran O'Brien. The film screened in Cannes Film Festival and Sundance Film Festival and had a world-wide theatrical release. Stilley asked that director Michael Winterbottom refer to her simply by her character's name in interviews about the film at the beginning to protect the artistic integrity of the film. Her second credit solidified her standing in Britain's indy film scene starring in the satirical comedy Nathan Barley directed by Chris Morris for British television.
Stilley has since starred in American and British productions , including How to Loose Friends & Alienate People with Simon Pegg and Jeff Bridges, Miss Marple with Benedict Cumberbatch and has worked again with Winterbottom on a BBC Two comedy The Trip with Steve Coogan and Rob Brydon. She appeared in feature articles in Vogue, In Style UK, The Face, Harper's Bazaar, Black Book Magazine, Elle and presented Fashion Awards to Giles Deacon at Elle Style Awards and Best Newcomer Award to Christopher Kane for the British Fashion Awards.