Tom Papa, Michael Ian Black and Seth Herzog put weird, unusual and over-the-top hypotheses to the test in a breezy, lighthearted and often hilarious manner. The "mad scientists" challenge one another in each hourlong episode with three different theories and then go about trying to prove their validity using either in-studio or remote experiments. Scientific professionals explain the why and the how behind some of the surprising results, and once each host has defended his honor by carrying out an experiment, the studio audience weighs in. Whose fact is the most-impressive, outrageous or interesting? Does the stall closest to the door in a public restroom really have the least amount of germs? Does the color red actually make bulls angry? Can you stretch a swim cap so wide that an adult can fit inside it? With questions like these, Duck Quacks Don't Echo experiments with the fun side of science.