Ali Vincent changed her life by losing 112 pounds during the fifth season of the reality series The Biggest Loser, becoming the first female winner in the show's history. In Live Big with Ali Vincent, Vincent goes on a personal journey across the United States on a mission to help others change their lives and discover their true selves. Working with other lifestyle experts, Vincent motivates people to take control of their lives in order to achieve better futures. Viewers get to see the subjects' complete transformations through before-and-after segments. The show also includes segments offering viewers advice on topics including shopping, cooking and exercising.