Hitmen follows two best friends trying to make their way in the world with only each other to rely on. They also just happen to kill people for a living. Having stumbled into a career in contract killing, misfits Fran and Jamie are not your typical killers for hire. Working out of their scruffy van, each episode follows the hapless duo as they try to carry out their latest hit, inevitably derailed by incompetence, bickering, and inane antics. As each hit goes south, our (anti)heroes are thrown into one bizarre misadventure after another, each full of oddball characters and unexpected dilemmas.