While Beth and the rest of the team search for a new office and enjoy a hike at Manoa Falls Trail, Dog and David go to Las Vegas, Nevada to hunt for Jamie Jungers, one of Tiger Woods' alleged mistresses, as a favor for a friend. After four days of searching, a criminal informant leads Dog to his house where he claims Jamie is, but his shifty behavior draws the suspicions of Dog, David and local bail agent Vic. After taking Jamie into custody to be sent back to Kansas to stand trial, Dog, David and Vic notice one of the men from the house following them. Concerned, Dog alerts the Las Vegas police who arrest the man who Dog suspects was intending to kill Jamie. Jamie expresses remorse for her drug habit and a desire to turn her life around for the better. After returning to Hawaii, Dog holds a garage sale for the contents of his office with people from all over the world coming. Three months later, Dog video chats with Jamie who has entered rehab and is working on bettering her life.

Beth has received the devastating news that her cancer is incurable with no chance of survival. Having stopped her chemo treatments due to the side effects, Dog and Beth begin discussing other options. Now back home, Dog and the team are contacted by Leland to chase one of his fugitives, Manuel, who has fled to Hawaii. Manuel's brother was previously taken down by Leland's son Dakota on his first bounty and Dog caught his father. Within hours, the team is able to capture Manuel with the help of his girlfriend's grandfather and Dog predicts that Manuel will likely be going to prison for many years. Dog is later contacted by Leland to capture Cristin, a girl who has skipped bail and on whom three cases rests. With Dakota having a baby on the way in a matter of weeks, he carries a baby doll around on the hunt to practice. Cristin is caught by Dakota while trying to escape out a window and is found with a significant amount of methamphetamine in her bedroom. During the two hunts, Leland's prized Hummer gets banged up. After the hunt, Dakota learns that his wife has gone into labor six weeks early and she gives birth to his son.

Pain in Beth's throat sparks fear that her throat cancer has returned. Beth gets an MRI, but Dog suspects she skips the appointment with the results due to the possibility of bad news. Still in Alabama following the successful Alabama Sweep, Dog and his team agree to help Leland hunt down another fugitive. Due to Beth feeling unwell on the second night of the hunt, most of Dog's team remains behind to work the phones and are replaced by some of Leland's team, including Leland's wife and his son Cobie who is on his very first bounty hunt. On the third day, the fugitive agrees to surrender, but never shows up. Dog and Beth are forced to leave the team to finish the job due to Beth's appointment regarding her cancer in LA. The next day, the team launches a daytime raid on the fugitive's property and finally catch him, resulting in the team getting put in the newspaper.

Having gotten news of her cancer diagnosis, Beth is determined to continue working. Dog's team goes after the most wanted man in Hawaii who has sixty-eight charges against him, stated to be more than Al Capone, and his son Willie Boy. Following a near-deadly encounter with Willie Boy, Dog's team unexpectedly catches his father but vows not to stop until they catch Willie Boy too.