Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison James Corrigan as Isaac Levido Simon Paisley Day as Dominic Cummings Jimmy Livingstone as Chris Whitty Shri Patel as Rishi Sunak Philip Buck as Martin Reynolds Derek Barr as Lee Cain Simon Lowe as James Slack Joe Bannister as Jack Doyle Ben Lloyd-Hughes as Ben Gascoigne Lee Comley as Ben Ravin J. Ganatra as Roshan Roisin Rae as Sally Heather Peace as Mary Wakefield Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Ruth Redman as Yvonne Doyle Olivier Huband as Jamie Richard Vadon as Himself Greta Bellamacina as Cleo Watson Isabella Javor as Lara Kate Lawson as Herself Tim Harford as Himself Adrian Harris as Duncan Selbie Anna Calder-Marshall as Charlotte Sam Phillips as Rob Anthony Howell as Neil Ferguson Julia Farino as Amanda Pritchard Simon Treves as NHS Medical Director Rick Bacon as Graham Medley Daniel Marot as Milo Sam Rathore as Sami Noel White as Richard Horton Tom Nguyen as Jonathan Van Tam Martin Fisher as Joe Andrew Ehrensperger as Theo Ruth Alexander Rubin as Herself Zoë Aldrich as Sarah Gilbert Robert Heard as Ben Warner Belinda Lang as Josephine Gwynne McElveen as Dream Woman John L. Armstrong as Procurement Manager Greg Haiste as Peter Horby Sam Patrick as John Edmunds Christopher Reynalds as Michael Gove Charles Dance as Max Hastings Oli Higginson as Saul James Allen as Family Court Judge Pat Brocklehurst as Resident Jade Leonce as Mandy Jimmy Cosgrove as Public Health England Worker Mike Truelove as Steve Walsh Natasha Lewis as NHS Rep Dr Nathalie MacDermott as Herself Ngee Kiang Goh as Gabriel Leung Benjamin Wok as Li Wen Liang Louise Morell as Teresa Lambe Doug Colling as Ben Reynah Rita as Munira Mirza Robin Morgan as Colin Kuran Dohil as Sonia Khan Mark Hampton as George Gao Baely Saunders as Journalist