Segura was born on July 3, 1992 in Washington, D.C. He is an American born of Colombian descent. He graduated from Winston Churchill High School in Potomac, Maryland. In 2013, he made his acting debut in the 2013 crime thriller film, 5th Street. Following on from his first role, Segura won other roles on a variety of TV shows including The Middle, Silicon Valley and Faking It. In 2015, Segura was cast as Benjamin in the underwater survival thriller film 47 Meters Down which was released in theaters on June 16, 2017.
In 2016, Segura was cast in the series regular role of Gustavo Acosta on the second season of MTV's Scream.