Giacomo Gianniotti is an Italian-Canadian actor, director and producer working in film, television and theatre. He was born on June 19, 1989 in Rome, Italy. Gianniotti emigrated with his family at a young age and grew up in Toronto, Ontario, Canada. He splits his time between Toronto, Rome and Los Angeles. Gianniotti is bilingual working both in English and Italian. He graduated from Humber College's Theatre Program and has also completed an actor's residency at Norman Jewison's Canadian Film Centre, in Toronto.
Gianniotti made his acting debut in the Italian television series Medicina Generale in 2010. He went on to play recurring roles in the television series Reign (2013) and Murdoch Mysteries (2013–2014). From 2015 to 2021, Gianniotti played Dr. Andrew DeLuca in the medical drama series Grey's Anatomy.