Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison Philip Buck as Martin Reynolds Simon Paisley Day as Dominic Cummings James Corrigan as Isaac Levido Derek Barr as Lee Cain Shri Patel as Rishi Sunak Jimmy Livingstone as Chris Whitty Wasim Zakir as Amir Hamdi Lee Comley as Ben Ravin J. Ganatra as Roshan Salima Saxton as Teena Ben Lloyd-Hughes as Ben Gascoigne Justin Edwards as Mark Sedwill Roisin Rae as Sally Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Helen Monks as Jodie Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Rina Mahoney as Julie Olivier Huband as Jamie Adrian Harris as Duncan Selbie Ruth Redman as Yvonne Doyle Kate Lawson as Herself Richard Vadon as Himself Albin Calderon as Manny Tim Harford as Himself Anthony Howell as Neil Ferguson Sam Phillips as Rob Anna Calder-Marshall as Charlotte Julia Farino as Amanda Pritchard Josephina Holroyd as Andrea Robert Heard as Ben Warner Tom Nguyen as Jonathan Van Tam Simon Treves as NHS Medical Director Sam Rathore as Sami Martin Fisher as Joe Rick Bacon as Graham Medley Tim Wallers as Simon Stevens Angela Wynter as Sarah Boateng Daniel Kobbina as Steve Jim Whelan as Des's Dad Andrea Waite as Sue Mickey Thompson as Des Bob Hopkinson as Resident Edward Ofosu-Osei as Tony Boateng Georgia Bowers as Landermeads Carer Caroline Bowers as Landermeads Carer Jane Bertish as Claire Green Hannah Figgens as Landermeads Carer Michael Amariah as Mr Ojo's Son Mark Lewis as Steven Green Shelley MacDonald as Imam Gala Gordon as Lizzie Christopher D. Grace as Marc Warner Jen Lim as Nurse Simon Molloy as Valerie's Dad Helen Ugwu as Tom's Wife Mary Greencroft as Brian's Wife Adam Jawed as Zulfi India Startford as Landermeads Carer Matt Weyland as Meag Laura June Hudson as Resident Ros Heath as Landermeads Manager Tony Timberlake as Doctor Bindni Karia as PHE Office Daniel Jack as Young Boris Johnson Jo McInnes as Sonja Adwoa Akoto as Sam Amy Shindler as Valerie April Kelly as Grange Head Office John Alastair as Army Colonel Euan Macnaughton as Public Health England, Medical Advisor Damian Quinn as MHA Manager