Danger Mouse and Penfold receive a crash course in the customs of America's oldest holiday when they cover for Jeopardy Mouse as she takes time off for Thanksgiving. After barely escaping from the war zone of a Black Friday sale, they find themselves back at Jeopardy's apartment. DM prepares to tuck into the plentiful Thanksgiving spread when Hissteria and Ham Hands rise out of the dishes. They announce their newly formed coalition and joint plans to vanquish America. DM sticks to his stand-in duties and refuses Jeopardy's help as he and Penfold follow Hissteria and Ham Hands' trail. They find the villainous pair hijacking the Thanksgiving Day parade - launching a gas attack from the air that will turn everything in sight to stuffing.