Dr. Emmet Cole, beloved adventurer and television personality goes missing deep in the Amazon. After a fruitless search for him, his family and friends abandon hope and hold a memorial service to commemorate his amazing life. His grieving wife, Tess, reluctantly tries to face the reality that her husband is gone, while her son, Lincoln, is more than ready to bury his past. Six months later Emmet's location beacon mysteriously begins to relay a signal. Tess persuades Lincoln to join her and Emmet's film crew on a journey through the Amazon to find him, a journey on which horrifying and almost mythical events will push them to their limits.