Pinkerton agent Charles Siringo and stage star Nance O'Keefe, who grows more desperate in her search for her missing brother, have been outplayed by Lizzie. But now they join forces against her. The sleazy new boss of Fall River's underworld, Skipjack, gleefully exploits a lethal secret Lizzie wants hidden. A haughty neighbor incites Lizzie's wrath by mistreating her dog. Worst of all, a romance threatens to come between Lizzie and her beloved her sister, Emma. When Nance uses her wiles to get Skipjack to spill his guts, her frenzied revenge against Lizzie spills blood... just not the blood Nance intended. Meantime, Lizzie mops up her animal-abusing neighbor with a spill of a different sort.