Confusion reigns on Earth as Queen Gertrude of Genovia sacks her cabinet, invites all the world's leaders to attend a conference at her palace and starts behaving very strangely. It soon emerges that Dr. Mu has shrunk himself down to the size of a single bacterium, transported himself into her body and is now controlling her! When Rufus decides to go after him, teaming up with a pair of royal brain cells, things don't go quite according to plan.
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