Guest Stars Ophelia Lovibond as Carrie Symonds Neil Stuke as Senior Civil Servant, DoH Andrew Buchan as Matt Hancock Aimée Kelly as Alison James Corrigan as Isaac Levido Shri Patel as Rishi Sunak Simon Paisley Day as Dominic Cummings Philip Buck as Martin Reynolds Derek Barr as Lee Cain Jimmy Livingstone as Chris Whitty Salima Saxton as Teena Simon Lowe as James Slack Lee Comley as Ben Justin Edwards as Mark Sedwill Michael Colgan as Gabriel Milland Joe Bannister as Jack Doyle Ben Lloyd-Hughes as Ben Gascoigne Wasim Zakir as Amir Hamdi Tom Andrews as Tom Armstrong Heather Peace as Mary Wakefield Greta Bellamacina as Cleo Watson Olivier Huband as Jamie Isabella Javor as Lara Albin Calderon as Manny Sam Dutton as DoH Official Orson Berthier Ronald as Cedd Andrew Ehrensperger as Theo Daniel Marot as Milo Hiten Patel as Downing Street Security Guard Simon Treves as NHS Medical Director Angela Wynter as Sarah Boateng Simon Kunz as Andrew Mills Jane Bertish as Claire Green Patrick Grant as Cookson and Clegg Mark Lewis as Steven Green Tim Berrington as John Newton Bob Hopkinson as Resident Lindsey Riding as Nurse Olivia-Rose Burton as Cassia Rizwan Khan as Downing Street Doctor Hannah Figgens as Landermeads Carer Caroline Bowers as Landermeads Carer Georgia Bowers as Landermeads Carer Edward Ofosu-Osei as Tony Boateng Ajay Chabra as Jin Sahota Keshini Misha as Rubaya Sandra Voe as Morag Darryl Mundoma as Asale Child Gilly Daniels as Resident Angela Carruthers as Factory Manager Edward Cole as Durham Police Officer Jaeceena Anderson as Asale Child Jessica Hof as DoH Official Timothy Edward Bartholomew as Robert Keshav Shree as Dentist Michelle Asante as Grace Gbolahan Obisesan as Frank James McNicholas as Deloitte Advisor Freddie Meredith as Adam Green Carly Bawden as Jo Green Ross Hatt as Norwich Doctor