Guest Stars Camilla Luddington as Dr. Jo Wilson Jason George as Dr. Ben Warren Jerrika Hinton as Dr. Stephanie Edwards Gaius Charles as Dr. Shane Ross Tessa Ferrer as Dr. Leah Murphy Tina Majorino as Dr. Heather Brooks Justin Bruening as Matthew Taylor Michael Buie as Paul Dawson Charles Michael Davis as Dr. Jason Myers Hilarie Burton Morgan as Dr. Lauren Boswell Jennifer Bassey as Nancy Dawson LisaGay Hamilton as Dr. Connie Ryan Co Starring Payton Silver as Dr. A. Knox Nicole Rubio as Paramedic Nicole Cummins Teresa Huang as Nurse Ruth Kate Mines as Nurse Gloria Kyle Silverstein as Ethan Dawson David Haley as Paramedic #2 Cynthia Youngblood as ER Nurse Mike Holley as Leon Frankie Ingrassia as Tyler's Mom Jeff Howard as Tyler's Dad Andy Forrest as Maintenance Worker