April and Dr. Halstead handle an alcoholic homeless man with a broken leg, but they don't see eye to eye on how to best treat his illness. Still grieving the death of her late husband, Dr. Manning experiences a medical event after realizing her wedding ring has gone missing. Dr. Charles and Sarah treat two elderly women with the exact same symptoms, but uncover a surprise that links the two cases together. Dr. Downey and Dr. Rhodes operate on a patient refusing their recommended treatment due to religious reasons. Meanwhile, a frustrated Dr. Halstead considers a job offer in California.