Christine Harnos was born on February 2, 1968 in Queens, New York. She was raised in Brooklyn and later on the North Shore of Long Island. In 1986 she signed with Elite Models and worked in both New York and Japan. In 1987 she was cast as the female lead in Disney's The Rescue. From 1994-2003 she appeared as Jennifer Greene on the award winning TV series ER.
In 2003 Christine took a hiatus from acting to pursue a degree in child development at Mills College. In 2006 she helped co-create Circus Remedy, an organization that arranges for circus performers to visit patients at children's hospitals, camps for terminally ill children, hospices, and refugee camps. She continues to serve as its executive director.