For most physicians, the Hippocratic oath is sacred. But for one Chicago doctor, who is indebted to the mafia, saving lives isn't her only concern. The Mob Doctor is a fast-paced medical drama featuring a brilliant young female cardiothoracic surgeon who is split between two distinct worlds as she juggles her promising medical career with her lifelong debt as a doctor to Chicago's Southside mob. Dr. Grace Devlin is a top resident at Chicago's Roosevelt Medical Center. Smart and self-assured, she's heralded as one of the country's most promising young surgeons. But family ties keep her glued to her Southside roots. To pay off her brother's life-threatening gambling debt, she makes a deal with the devil and agrees to work "off book" for the mafia men she once despised. During the day, Grace must deal with the emotionally compelling cases at Roosevelt Medical - a toddler in need of a heart transplant, an elderly man desperate to donate a lung to his sick wife, the mass chaos in the wake of a two-train collision on the 'L.' But in her other vastly different world, she must juggle an onslaught of mob-related demands, including operating in mob-sanctioned locations, removing bullets from dead bodies to hide incriminating evidence, saving a juiced-up race horse and covertly helping an aging mobster with his erectile dysfunction. All the while, Grace must keep her dual life a secret from everyone: her protective best friend, Nurse Roberta "Ro" Angeli; her handsome, blue-blooded boyfriend, Dr. Brett Robinson; her boss at Roosevelt Medical and Chief of Surgery, Dr. Stafford White; her rival, Dr. Olivia Watson even her well-meaning screw-up brother, Nate, and her overly dramatic mother, Daniella. The only one who knows the true scope of Grace's activities is the man to whom Grace owes her debt: the charming and diabolical Southside mob boss Constantine Alexander, an oddly compassionate killer whose relationship with Grace is more than it seems. Recently released from prison, the former head of the Chicago mob looks to reclaim his place in the organization, with the help of his right-hand associate - and Grace's ex-boyfriend - Franco. As Grace tries to heed the demands of these two conflicting worlds - not to mention the needs of her own slightly dysfunctional family - her moral center comes into direct conflict with the very immoral things she's asked to do. But with nerves of steel and a tough-as-nails exterior, she somehow manages to make it all work - at least for now.