From the distinct comedic point of view of Denis Leary and Bob Fisher, "Sirens" follows three of Chicago's best EMTs whose sometimes silly, self-righteous and even self-destructive personalities make them unqualified for sustaining relationships, friendships and most occupations. They are, however, uniquely qualified for saving anyone who winds up in their ambulance. Johnny (Michael Mosley) is a good-looking, sports-loving, Chicago EMT working with his best friend Hank (Kevin Daniels). Brian (Kevin Bigley) is a wide-eyed and excitable new EMT who still lives with his parents. Jessica McNamee will play the female lead, Theresa, a smart female cop with the Chicago PD who still loves her ex Johnny, but ultimately had to move on when he wouldn't commit.