Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Aimée Kelly as Alison Neil Stuke as Senior Civil Servant, DoH Simon Paisley Day as Dominic Cummings James Corrigan as Isaac Levido Jimmy Livingstone as Chris Whitty Shri Patel as Rishi Sunak Philip Buck as Martin Reynolds Derek Barr as Lee Cain Simon Lowe as James Slack Lee Comley as Ben Joe Bannister as Jack Doyle Ben Lloyd-Hughes as Ben Gascoigne Ravin J. Ganatra as Roshan Roisin Rae as Sally Heather Peace as Mary Wakefield Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Ruth Redman as Yvonne Doyle Olivier Huband as Jamie Richard Vadon as Himself Greta Bellamacina as Cleo Watson Isabella Javor as Lara Kate Lawson as Herself Tim Harford as Himself Adrian Harris as Duncan Selbie Anthony Howell as Neil Ferguson Anna Calder-Marshall as Charlotte Sam Phillips as Rob Julia Farino as Amanda Pritchard Martin Fisher as Joe Daniel Marot as Milo Andrew Ehrensperger as Theo Robert Heard as Ben Warner Zoë Aldrich as Sarah Gilbert Ruth Alexander Rubin as Herself Simon Treves as NHS Medical Director Noel White as Richard Horton Tom Nguyen as Jonathan Van Tam Rick Bacon as Graham Medley Sam Rathore as Sami Belinda Lang as Josephine Christopher Reynalds as Michael Gove Gwynne McElveen as Dream Woman Sam Patrick as John Edmunds John L. Armstrong as Procurement Manager Greg Haiste as Peter Horby Charles Dance as Max Hastings Oli Higginson as Saul Jimmy Cosgrove as Public Health England Worker Jade Leonce as Mandy Pat Brocklehurst as Resident Mike Truelove as Steve Walsh Dr Nathalie MacDermott as Herself Natasha Lewis as NHS Rep Ngee Kiang Goh as Gabriel Leung Benjamin Wok as Li Wen Liang Louise Morell as Teresa Lambe Doug Colling as Ben Reynah Rita as Munira Mirza Robin Morgan as Colin Kuran Dohil as Sonia Khan James Allen as Family Court Judge Mark Hampton as George Gao Baely Saunders as Journalist