Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Aimée Kelly as Alison Neil Stuke as Senior Civil Servant, DoH Simon Paisley Day as Dominic Cummings James Corrigan as Isaac Levido Philip Buck as Martin Reynolds Derek Barr as Lee Cain Shri Patel as Rishi Sunak Jimmy Livingstone as Chris Whitty Salima Saxton as Teena Lee Comley as Ben Wasim Zakir as Amir Hamdi Ravin J. Ganatra as Roshan Ben Lloyd-Hughes as Ben Gascoigne Justin Edwards as Mark Sedwill Roisin Rae as Sally Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Helen Monks as Jodie Rina Mahoney as Julie Alec Nicholls as Patrick Vallance Joan Walker as Sharon Peacock Adrian Harris as Duncan Selbie Olivier Huband as Jamie Ruth Redman as Yvonne Doyle Kate Lawson as Herself Richard Vadon as Himself Albin Calderon as Manny Tim Harford as Himself Anthony Howell as Neil Ferguson Anna Calder-Marshall as Charlotte Sam Phillips as Rob Julia Farino as Amanda Pritchard Robert Heard as Ben Warner Tom Nguyen as Jonathan Van Tam Simon Treves as NHS Medical Director Sam Rathore as Sami Tim Wallers as Simon Stevens Martin Fisher as Joe Rick Bacon as Graham Medley Josephina Holroyd as Andrea Angela Wynter as Sarah Boateng Jane Bertish as Claire Green Mark Lewis as Steven Green Daniel Kobbina as Steve Andrea Waite as Sue Mickey Thompson as Des Bob Hopkinson as Resident Edward Ofosu-Osei as Tony Boateng Georgia Bowers as Landermeads Carer Caroline Bowers as Landermeads Carer Hannah Figgens as Landermeads Carer Jim Whelan as Des's Dad Michael Amariah as Mr Ojo's Son Shelley MacDonald as Imam Gala Gordon as Lizzie Christopher D. Grace as Marc Warner Laura June Hudson as Resident Jo McInnes as Sonja Jen Lim as Nurse Simon Molloy as Valerie's Dad Helen Ugwu as Tom's Wife Mary Greencroft as Brian's Wife Adam Jawed as Zulfi India Startford as Landermeads Carer Matt Weyland as Meag Tony Timberlake as Doctor Ros Heath as Landermeads Manager Bindni Karia as PHE Office Daniel Jack as Young Boris Johnson Adwoa Akoto as Sam Amy Shindler as Valerie April Kelly as Grange Head Office John Alastair as Army Colonel Euan Macnaughton as Public Health England, Medical Advisor Damian Quinn as MHA Manager