"You are my sister. You're supposed to drive me crazy." Twenty-eight-year-old organization freak Valerie Tyler loves her 16-year-old sister Holly. Even if Holly is rambunctious. Spontaneous. Impulsive. Disconcerting. And definitely disorganized. Then Holly moves in with Val, and the sisters discover they may make better siblings than roomies. Amanda Bynes and Jennie Garth star as the Tylers and Simon Rex and Wesley Jonathan star as two of the men in their lives in this bright, giddy comedy set in Manhattan - and in the hearts of sisters everywhere.