The time is 1897 and the territory is the west. Veteran cowboy Print Ritter is ready to trade his life on the range for a ranch of his own. All he has to do is run 500 horses from Oregon to Wyoming to earn the money. He recruits his estranged nephew Tom Harte for the ride, and as the two set out the only trouble they expect is bad weather and strays.
But it's not long before their path crosses with that of a low-life trafficker and the five innocent Chinese girls he's delivering to certain ruin in a lawless mining town. In a sudden twist of fate and act of justice, the five girls become Print and Tom's responsibility, turning their horse drive into a makeshift wagon train.
As the small band proceeds east, their path intersects with horse-thieves and gun-slingers, madams and mercenaries, native warriors and runaway whores. Each encounter threatens their drive and frequently their lives, but Print and Tom always put honor first - even if it means firing a gun or adding a new passenger. Though the trail they've chosen is the hard one, it's the one that leads to second chances at life, love, and redemption for them all.