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Appearances
The Meaning of Life with Joe Duffy
Main cast, played by Gay Byrne
- Episode 1x01: Colin Farrell (Apr 19, 2009)
- Episode 1x02: Gerry Adams (Apr 26, 2009)
- Episode 1x03: Maeve Binchy (May 3, 2009)
- Episode 1x04: Ronan Keating (May 10, 2009)
- Episode 1x05: Sinéad O'Connor (May 17, 2009)
- Episode 1x06: Neil Jordan (May 24, 2009)
- Episode 2x01: Gabriel Byrne (Jan 17, 2010)
- Episode 2x02: Tommy Tiernan (Jan 24, 2010)
- Episode 2x03: Brenda Fricker (Jan 31, 2010)
- Episode 2x04: Bertie Ahern (Feb 7, 2010)
- Episode 2x05: Mary Robinson (Feb 14, 2010)
- Episode 2x06: Edna O'Brien (Feb 21, 2010)
- Episode 3x01: Terry Wogan (Sep 26, 2010)
- Episode 3x02: Fionnula Flanagan (Oct 3, 2010)
- Episode 3x03: Deepak Chopra (Oct 10, 2010)
- Episode 3x04: Ian Paisley (Oct 17, 2010)
- Episode 3x05: Mícheál Ó Muircheartaigh (Oct 24, 2010)
- Episode 3x06: Dana Rosemary Scallon (Nov 7, 2010)
- Episode 4x01: Michael Parkinson (Mar 6, 2011)
- Episode 4x02: Brendan O'Carroll (Mar 13, 2011)
- Episode 4x03: Mark Patrick Hederman (Mar 20, 2011)
- Episode 4x04: Brian Cody (Mar 27, 2011)
- Episode 4x05: Martin Sheen (Apr 3, 2011)
- Episode 4x06: Ben Dunne (Apr 10, 2011)
- Episode 5x01: Andrea Corr (Jan 8, 2012)
- Episode 5x02: Paddy Moloney (Jan 15, 2012)
- Episode 5x03: Fr. Shay Cullen (Jan 22, 2012)
- Episode 5x04: Richard Branson (Jan 29, 2012)
- Episode 5x05: Bob Geldof (Feb 5, 2012)
- Episode 5x06: Mary Byrne (Feb 12, 2012)
- Episode 6x01: Mary McAleese (Oct 7, 2012)
- Episode 6x02: Noel Gallagher (Oct 14, 2012)
- Episode 6x03: Sean Gallagher (Oct 21, 2012)
- Episode 6x04: Niall Quinn (Oct 28, 2012)
- Episode 6x05: Norah Casey (Nov 4, 2012)
- Episode 7x01: Colm Tóibín (Jan 6, 2013)
- Episode 7x02: J. P. Donleavy (Jan 13, 2013)
- Episode 7x03: John Lonergan (Jan 20, 2013)
- Episode 7x04: Maureen Gaffney (Jan 27, 2013)
- Episode 7x05: Maria Doyle Kennedy (Feb 3, 2013)
- Episode 7x06: Christina Noble (Feb 10, 2013)
- Episode 7x07: Bono (Jun 22, 2013)
- Episode 8x01: Colm Wilkinson (Oct 6, 2013)
- Episode 8x02: Emily O'Reilly (Oct 13, 2013)
- Episode 8x03: Fr Peter McVerry (Oct 20, 2013)
- Episode 8x04: Celine Byrne (Oct 27, 2013)
- Episode 8x05: Imelda May (Nov 3, 2013)
- Episode 9x01: Majella O'Donnell (May 4, 2014)
- Episode 9x02: Rory O'Neill (May 11, 2014)
- Episode 9x03: Sean O'Sullivan (Jun 1, 2014)
- Episode 9x04: Eamon Dunphy (Jun 8, 2014)
- Episode 9x05: David Puttnam (Jun 15, 2014)
- Episode 9x06: Enda Kenny (Jun 22, 2013)
- Episode 10x01: Cecila Ahern (Jan 25, 2015)
- Episode 10x02: Stephen Fry (Feb 1, 2015)
- Episode 10x03: Barry McGuigan (Feb 8, 2015)
- Episode 10x04: Mary Black (Feb 15, 2015)
- Episode 10x05: Earl Spencer (Mar 22, 2015)
- Episode 10x06: Dr Rowan Williams (Mar 1, 2015)
- Episode 11x01: Hozier (Sep 27, 2015)
- Episode 11x02: Joan Burton (Oct 4, 2015)
- Episode 11x03: Diarmuid Gavin (Oct 11, 2015)
- Episode 11x04: Prof. Richard Dawkins (Oct 18, 2015)
- Episode 11x05: Sr Stanislaus Kennedy (Oct 25, 2015)
- Episode 11x06: Eckhart Tolle (Nov 1, 2015)
- Episode 12x01: Ruby Wax (Jan 10, 2016)
- Episode 12x02: Anna May McHugh (Jan 17, 2016)
- Episode 12x03: Dolores Keane (Jan 24, 2016)
- Episode 12x04: Eoin Colfer (Feb 14, 2016)
- Episode 12x05: Jonathan Sacks (Feb 7, 2016)
- Episode 12x06: Peter Sutherland (Mar 6, 2016)
- Episode 13x01: John Sheahan (Oct 16, 2016)
- Episode 13x02: Garry Hynes (Oct 23, 2016)
- Episode 13x03: André Rieu (Oct 30, 2016)
- Episode 13x04: Joanne O'Riordan (Nov 6, 2016)
- Episode 13x05: Shaykq Al Quadri (Nov 13, 2016)
- Episode 13x06: Archbishop Charles J. Brown (Nov 20, 2016)