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Appearances
The Megan Mullally Show
Main cast, played by Megan Mullally
- Episode 1x01: Will Ferrell, Jenny McCarthy (Sep 18, 2006)
- Episode 1x02: Eva Mendes, "So You Think You Can Dance", Granny Basketball (Sep 19, 2006)
- Episode 1x03: Lisa Kudrow, 10 year-old Opera Singer, Adam Rodriguez (Sep 20, 2006)
- Episode 1x04: Carol Burnett, Rainn Wilson, Hollerin' Championships (Sep 21, 2006)
- Episode 1x05: Felicity Huffman, 'Animal Guys' Paul Hahn and David Riherd, Enrique Murciano (Sep 22, 2006)
- Episode 1x06: Julia Louis-Dreyfus, Illusionist Criss Angel, Mario Lopez (Sep 25, 2006)
- Episode 1x07: Debra Messing, Fashion Makeover with Lucky Magazine, Omar Epps (Sep 26, 2006)
- Episode 1x08: George Lopez, Jennifer Finnigan, Vacuum Cleaning Genius, Tim Bagley At A Cher Convention (Sep 27, 2006)
- Episode 1x09: Sela Ward, Chris Noth (Sep 28, 2006)
- Episode 1x10: Patricia Heaton, Duane Martin, Jesse McCartney (Sep 29, 2006)
- Episode 1x11: Jane Kaczmarek, Masi Oka, Champion Cloggers (Oct 2, 2006)
- Episode 1x12: Tom Bergeron, Eric Stromer, Elizabeth Perkins (Oct 3, 2006)
- Episode 1x13: Tim Daly, Domino Magazine (Oct 4, 2006)
- Episode 1x14: Connie Britton, Michael Clark Duncan (Oct 5, 2006)
- Episode 1x15: Jennifer Love Hewiitt, Jonny Lee Miller, J. Xavier (Oct 6, 2006)
- Episode 1x16: Virginia Madsen, Noah Gray-Cabey, Around The Office (Oct 9, 2006)
- Episode 1x17: Marcia Cross, Clinton Kelly, Isaiah Washington (Oct 10, 2006)
- Episode 1x18: Molly Ringwald, OK Go (Oct 11, 2006)
- Episode 1x19: Wanda Sykes, Goran Visnjic, Ruben Studdard (Oct 12, 2006)
- Episode 1x20: Peter Gallagher, Nathan Burton, Tyler James Williams (Oct 13, 2006)
- Episode 1x21: Bradley Whitford, Shelley Morrison, Eric Mabius, Mario Vazquez, Phil Pfister (Oct 16, 2006)
- Episode 1x22: Cheyenne Kimball, Laura Linney, Ricardo Antonio Chavira (Oct 17, 2006)
- Episode 1x23: Merv Griffin, Kim Raver, Author Jennifer Egan (Oct 18, 2006)
- Episode 1x24: Rob Morrow, Rebecca Cole, Anne Heche, Joshua Bell (Oct 19, 2006)
- Episode 1x25: Josh Duhamel, Alison Lohman, Authors Mark Leyner and Bill Goldberg, Aly & AJ Michalka (Oct 20, 2006)
- Episode 1x26: Kristin Chenoweth, Jill Conner Browne, Nick & Aaron Carter, the Sweet Potato Queens (Oct 23, 2006)
- Episode 1x27: Jamie Lee Curtis, The Mystic Pixies, Amy Smart, Taylor Swift (Oct 24, 2006)
- Episode 1x28: Lauren Holly, Ruben Studdard, Daniel Dae Kim (Oct 25, 2006)
- Episode 1x29: Cloris Leachman, Jensen Ackles, Dog Halloween Costumes with Teri Austin, ecostylist Danny Seo (Oct 26, 2006)
- Episode 1x30: James Denton, Yahoo 9's Maria Sansone, Angela Kinsey, JoJo (Oct 27, 2006)
- Episode 1x31: Steven Weber, Audra McDonald (Oct 30, 2006)
- Episode 1x32: Neil Patrick Harris, Kevin Federline (Oct 31, 2006)
- Episode 1x33: Jamie Kennedy, Jeffrey Sebelia, Meat Loaf, Card Thrower Rick Smith (Nov 1, 2006)
- Episode 1x34: Clay Aiken, Tysonia Tschinga "real life" Dancing with the Stars (Nov 2, 2006)
- Episode 1x35: Sean Hayes, Eddie Cibrian, Dog Whisperer Cesar Millan, Author Mitch Albom (Nov 3, 2006)
- Episode 1x36: Barry Manilow, Parminder Nagra, Tim Bagley visits "America's Got Talent", Kid's Ballroom Dancing (Nov 6, 2006)
- Episode 1x37: Mark Harmon, Hip Hop Champions, Constance Zimmer, Melora Hardin (Nov 7, 2006)
- Episode 1x38: Kevin Nealon, Antonio Sabato Jr. (Nov 8, 2006)
- Episode 1x39: Bob Saget, sex educator Sue Johanson (Nov 9, 2006)
- Episode 1x40: Molly Sims, Andrea Bowen, The Ten Tenors, Celebrity trainer Michael Carson (Nov 10, 2006)
- Episode 1x41: Cheryl Hines, Tim Gunn, Thanksgiving Dog Adoption Fashion Show (Nov 13, 2006)
- Episode 1x42: David Hyde Pierce, Linda Cardellini, Taylor Ware (Nov 14, 2006)
- Episode 1x43: Patricia Arquette, Champion Pirouette Dancer, Daily Candy Trends (Nov 15, 2006)
- Episode 1x44: Dax Shepard, Tom Arnold, Kimberley Locke (Nov 16, 2006)
- Episode 1x45: Reba McEntire, Patrick Wilson, RBD (Nov 17, 2006)
- Episode 1x46: Tom Bergeron, Trista and Ryan, Benji Schwimmer, Rupert Boneham (Nov 20, 2006)
- Episode 1x47: Sharon Stone, Scott Foley, Rusty Schwimmer, Paz Vega, Danny Seo (Nov 21, 2006)
- Episode 1x48: Wayne Brady, Penguins Pete and Penny, Nestle Toll House Bake Sale Finalist (Nov 22, 2006)
- Episode 1x49: Camryn Manheim, Phil Pfister, James Lesure, Author Karen Rizzo (Nov 24, 2006)
- Episode 1x50: Neil Patrick Harris, Josh Radnor, Alyson Hannigan, Jason Segel and Cobie Smulders (Nov 27, 2006)
- Episode 1x51: David Boreanaz, Julianne Nicholson, Bianca Ryan (Nov 28, 2006)
- Episode 1x52: Matthew Broderick, Donald Faison, Brian Baumgartner, the Bucket Boys, Catherine Lloyd Burns (Nov 29, 2006)
- Episode 1x53: Tracy Morgan, Melissa Peterman, Jarod Miller, Eric Stromer (Nov 30, 2006)
- Episode 1x54: Carrie Fisher, Paul Rodriguez, Nadine Velazquez (Dec 1, 2006)
- Episode 1x55: Rosanna Arquette, Tom Green, Adrian Pasdar (Dec 4, 2006)
- Episode 1x56: Marla Sokoloff, Taylor Hicks, "Campus Ladies" (Dec 5, 2006)
- Episode 1x57: Phyllis Diller (Dec 6, 2006)
- Episode 1x58: Carson Kressley, Beau Bridges, Amy Sedaris (Dec 7, 2006)
- Episode 1x59: Wendie Malick, Janice Dickinson (Dec 8, 2006)
- Episode 1x60: John Stamos, Brenda Strong, Cris Judd, Tyrese (Dec 11, 2006)
- Episode 1x61: David James Elliott, Michael Ealy, Lisa Edelstein, magician Nathan Burton (Dec 12, 2006)
- Episode 1x62: Jeffrey Tambor, Tisha Campbell, designer Mark Montano, Hall & Oates (Dec 13, 2006)
- Episode 1x63: Shawn and Marlon Wayans, Taylor Hicks (Dec 14, 2006)
- Episode 1x64: Oded Fehr, Rob Morrow, Rhea Perlman, Sarah Rush (Dec 15, 2006)
- Episode 1x65: Howie Mandel, Jennie Garth, Ahmet Zappa, psychic medium Lisa Williams (Dec 18, 2006)
- Episode 1x66: Jane Seymour, David Conrad, Ken Davitian, Joshua Radin (Dec 19, 2006)
- Episode 1x67: Alfre Woodard, Milo Ventimiglia, Fantasia Barrino (Dec 20, 2006)
- Episode 1x68: Billy Ray Cyrus, Richard Simmons, authors of "Party Confidential" (Dec 21, 2006)
- Episode 1x69: Hall & Oates, Brian McKnight, Clay Aiken, José Feliciano, Kimberley Locke, Celtic Woman (Dec 22, 2006)
- Episode 1x70: Emily Procter, Tichina Arnold, Goo Goo Dolls (Jan 8, 2007)
- Episode 1x71: Natalie Cole, Craig Bierko, Dave Annable, Blaine Zuckerman (Jan 9, 2007)
- Episode 1x72: Tom Bergeron, Tim Daly, Will Ferrell, Allison Janney, Davy Jones, Chris Noth, Jerry Springer (Jan 15, 2007)
- Episode 1x73: Patricia Heaton, Cheryl Hines, Debra Messing, Christine Taylor (Jan 16, 2007)
- Episode 1x74: Josh Duhamel, Jamie Kennedy, George Lopez, Mario Lopez (Jan 17, 2007)
- Episode 1x75: Selma Blair, Kristin Chenoweth, Lisa Kudrow, Laura Linney, Julia Louis-Dreyfus (Jan 18, 2007)
- Episode 1x76: Chandra Wilson, Jesse Bradford, Clay Aiken (Jan 24, 2007)