Guest Stars Pierpaolo Spollon as Michelangelo Maria Vera Ratti as Lisa Del Giocondo Gianmarco Saurino as Lapo Mirko Zamperla as Burly Beggar Mattia Sonnino as Mattia Edan Hayhurst as Gian Galeazzo Sforza Kit Clarke as Jacopo Saltarelli Brice Martinet as King of France Luca Grispini as Guglielmo da Vinci Luca Guastini as Tornabuoni Erasmo Genzini as Dante Andrea Garofalo as Sforza Servant Alessandro Lui as Sforza Guard Robert Madison as Filippo Enoch Marrella as Lorenzo the Butcher Daniele De Angelis as Metello Christian Galizia as Knife Grinder Giacomo Mattia as Dye Factory Forman Alessandro Onorati as Borgia Guard Paolo Orlandelli as Soderini's Secretary Anna Elena Pepe as Dye Factory Woman Worker Nadia Ricci as Leonardo's Mother Alfie Rigby as Francesco da Vinci Nick Russo as da Vinci Servant Filippo Tirabassi as Pietro Andrea Vasone as Benci Servant Bruce McGuire as Abbott Bandelli Hugo Becker as Thierry Davide Iacopini as Machiavelli Matteo Lai as Thin Apprentice Andrea Dugoni as Deo Anton Alexander as Prior Vincenzo Clive Riche as Rector Lorenzo Profita as Brother Giovanni Paolo D. Bovani as Officer Bargello Sergio Albelli as Amerigo Benci Lidia Vitale as The Hag Tommaso Basili as Duke of Urbino Jacopo Fazzini as Carpenter Freddy Drabble as Alchemist Mattia Napoli as Young Piero Lorenzo Adorni as Francesco Giocondo Tommaso Amadio as Advocate Ettore Bernabei as Leonardo Florence Apprentice Al Bettini as Protester Michele Bevilacqua as Physician Yuri Casagrande as Assassin Matthew Steer as Sforza Chamberlain Sebastian Dimulescu as Young Leonardo 7 y.o.