Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Aimée Kelly as Alison Neil Stuke as Senior Civil Servant, DoH James Corrigan as Isaac Levido Derek Barr as Lee Cain Shri Patel as Rishi Sunak Simon Paisley Day as Dominic Cummings Philip Buck as Martin Reynolds Jimmy Livingstone as Chris Whitty Joe Bannister as Jack Doyle Ben Lloyd-Hughes as Ben Gascoigne Simon Lowe as James Slack Ravin J. Ganatra as Roshan Salima Saxton as Teena Wasim Zakir as Amir Hamdi Lee Comley as Ben Tom Andrews as Tom Armstrong Roisin Rae as Sally Michael Colgan as Gabriel Milland Justin Edwards as Mark Sedwill Heather Peace as Mary Wakefield Helen Monks as Jodie Rina Mahoney as Julie Isabella Javor as Lara Tim Wallers as Simon Stevens Andrew Ehrensperger as Theo Daniel Marot as Milo Hiten Patel as Downing Street Security Guard Orson Berthier Ronald as Cedd Jim Whelan as Des's Dad Mickey Thompson as Des Gwynne McElveen as Dream Woman Henry Garrett as Archie Bland Max Dowler as Guardian Editor Chris Patten as Robert Brooke Havana Bailey as Jogger Olivia-Rose Burton as Cassia Lindsey Riding as Nurse Rizwan Khan as Downing Street Doctor Andrea Waite as Sue Anthony Shuster as Matthew Weaver Dan Fredenburgh as Dr Nick Price Matthew Douglas as Dr Nick Hatt John Johnston as Resident Sarah Belcher as Nora John Dutton as Frank Polly Christopher as Doctor Ruth Evans as Frank's Wife Jen Painter as Jenny McGee Gala Botero as The Guardian Journalist Alex Wiltshire as Grange Carer Joe Almeida as Luis Patarma Gareth Lewis as Doctor
