Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Neil Stuke as Senior Civil Servant, DoH Aimée Kelly as Alison Shri Patel as Rishi Sunak Philip Buck as Martin Reynolds Jimmy Livingstone as Chris Whitty James Corrigan as Isaac Levido Derek Barr as Lee Cain Simon Paisley Day as Dominic Cummings Lee Comley as Ben Justin Edwards as Mark Sedwill Ben Lloyd-Hughes as Ben Gascoigne Ravin J. Ganatra as Roshan Salima Saxton as Teena Simon Lowe as James Slack Roisin Rae as Sally Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Wasim Zakir as Amir Hamdi Joe Bannister as Jack Doyle Heather Peace as Mary Wakefield Helen Monks as Jodie Rina Mahoney as Julie Isabella Javor as Lara Hiten Patel as Downing Street Security Guard Orson Berthier Ronald as Cedd Daniel Marot as Milo Tim Wallers as Simon Stevens Andrew Ehrensperger as Theo Henry Garrett as Archie Bland Gwynne McElveen as Dream Woman Brooke Havana Bailey as Jogger Chris Patten as Robert Mickey Thompson as Des Olivia-Rose Burton as Cassia Rizwan Khan as Downing Street Doctor Lindsey Riding as Nurse Andrea Waite as Sue Jim Whelan as Des's Dad Max Dowler as Guardian Editor Anthony Shuster as Matthew Weaver Matthew Douglas as Dr Nick Hatt Gareth Lewis as Doctor Dan Fredenburgh as Dr Nick Price Sarah Belcher as Nora John Johnston as Resident John Dutton as Frank Polly Christopher as Doctor Ruth Evans as Frank's Wife Jen Painter as Jenny McGee Gala Botero as The Guardian Journalist Alex Wiltshire as Grange Carer Joe Almeida as Luis Patarma
