Guest Stars Ophelia Lovibond as Carrie Symonds Andrew Buchan as Matt Hancock Aimée Kelly as Alison Neil Stuke as Senior Civil Servant, DoH Simon Paisley Day as Dominic Cummings Jimmy Livingstone as Chris Whitty Derek Barr as Lee Cain Philip Buck as Martin Reynolds Shri Patel as Rishi Sunak James Corrigan as Isaac Levido Simon Lowe as James Slack Joe Bannister as Jack Doyle Nina Beagley as Sally Wasim Zakir as Amir Hamdi Ravin J. Ganatra as Roshan Salima Saxton as Teena Tom Andrews as Tom Armstrong Michael Colgan as Gabriel Milland Justin Edwards as Mark Sedwill Joan Walker as Sharon Peacock Helen Monks as Jodie Heather Peace as Mary Wakefield Olivier Huband as Jamie Rina Mahoney as Julie Alec Nicholls as Patrick Vallance Adrian Harris as Duncan Selbie Albin Calderon as Manny Richard Vadon as Himself Kate Lawson as Herself Isabella Javor as Lara Greta Bellamacina as Cleo Watson Ruth Redman as Yvonne Doyle Tim Harford as Himself Anna Calder-Marshall as Charlotte Sam Dutton as DoH Official Josephina Holroyd as Andrea Orson Berthier Ronald as Cedd Zoë Aldrich as Sarah Gilbert Ruth Alexander Rubin as Herself Hiten Patel as Downing Street Security Guard Noel White as Richard Horton Simon Kunz as Andrew Mills Belinda Lang as Josephine Tim Delap as Dominic Raab Patrick Grant as Cookson and Clegg Chris Patten as Robert David Shaw Parker as Sir Paul Nurse Tim Berrington as John Newton Henry Garrett as Archie Bland Ajay Chabra as Jin Sahota Anthony Shuster as Matthew Weaver Max Dowler as Guardian Editor Brooke Havana Bailey as Jogger Elen Rhys as Physio - Janet Kate Fahy as Clare Edwards Andy Commins as Bluebell Woods Photographer Richard Teverson as John Penrose Simon Hepworth as Grant Shapps Russell Kilmister as Peter Frida Mosse-Williams as Pippa's Child Matilda Mosse-Williams as Pippa's Child Sam Lupton as Robert Jenrick Jeremy Armstrong as Himself David Kennaway as Tim Horlick Tabeer Tahir as Aysha Nicola McRoy as Kate Bingham Tom Slattery as Police Media Officer Robin Lees as Themselves Isabella Farchy as Deliotte Worker Emily Bowyer as Emily Gareth Crickmer as Dave Marc Richardson as Jens Wiechers Adam Jackson-Smith as Nick Hopkins Gavin Kitchen as Dave Edwards Dan March as Jesse Norman Shahid Ahmed as Factory Manager Jasmine Hyde as Pippa Crerar Johanne Murdock as Dido Harding Chloe Okura as Midwife - Hirut
