Special Guest Stars Nick Gehlfuss as Dr. Will Halstead Torrey DeVitto as Dr. Natalie Manning Guest Stars Frankie DeMaio as Owen Jeffrey Manning Merrin Dungey as Dr. Jennifer Kingston Tetona Jackson as Esme Lockhart Zach Appelman as Jeremy Lockhart Jamie Renee Smith as Larissa Taggart Gina Vitori as Emerald Atwell James Immekus as Miles Weller Jackson Dorfmann as Jasper Eaton Co Starring Lorena Diaz as Nurse Doris Marie Tredway as Nurse Trinidad "Trini" Campos Rasika Ranganathan as Dr. Asha Mallick Angel Yvonne as Charge Nurse Patrick Brambert as Security Guard Don Schultz Casey Hartnett as Device Rep Simone Finch Bradley Allen Meyer as Spa Employee Lola Rae as Nurse #2 Ashley Singh as Circulating Nurse