Special Guest Stars Nick Gehlfuss as Dr. Will Halstead Torrey DeVitto as Dr. Natalie Manning Guest Stars Frankie DeMaio as Owen Jeffrey Manning Tetona Jackson as Esme Lockhart Merrin Dungey as Dr. Jennifer Kingston Jamie Renee Smith as Larissa Taggart Zach Appelman as Jeremy Lockhart Gina Vitori as Emerald Atwell Jackson Dorfmann as Jasper Eaton James Immekus as Miles Weller Co Starring Lorena Diaz as Nurse Doris Marie Tredway as Nurse Trinidad "Trini" Campos Rasika Ranganathan as Dr. Asha Mallick Angel Yvonne as Charge Nurse Casey Hartnett as Device Rep Simone Finch Bradley Allen Meyer as Spa Employee Lola Rae as Nurse #2 Ashley Singh as Circulating Nurse Patrick Brambert as Security Guard Don Schultz
