Clarke started her career in 2012 as a production assistant on the short film Epithet, before working as a base runner and assistant director on The Hollow Crown. In 2013, she worked as an assistant director on I Give It a Year, a set producer assistant on Trance and a production assistant on Philomena.
In 2018, Clarke joined the fourth season of The Royals as an assistant to executive producer and writer's assistant.
In 2023, Clarke became a member of the writing team for A Million Little Things' fifth and final season, and co-wrote her first TV episode.
