Season 1
Episode: 1x01 | Airdate: Sep 29, 2013
Dr. William Masters, a successful doctor of obstetrics and gynecology, begins his controversial study of human sexuality. Dr. Masters recruits Virginia Johnson to be his secretary, but she quickly advances to be a valuable associate.
Episode: 1x02 | Airdate: Oct 6, 2013
The Provost shuts down the research when he hears about the couples study and Masters is forced to move it elsewhere. Dr. Masters blames Virginia and fires her, but keeps her on until he can find a replacement.
Episode: 1x03 | Airdate: Oct 13, 2013
A woman pregnant with quadruplets comes to the hospital and Dr. Haas lobbies for the case. A female gynecologist joins the staff. Both Dr. Masters and his wife learn a secret and both get what they want.
Episode: 1x04 | Airdate: Oct 20, 2013
Both Bill and Virginia have unexpected and unwelcome visitors at home. With the study back in the hospital, new participants are recruited. Ethan struggles to forget his feelings for Virginia.
Episode: 1x05 | Airdate: Oct 27, 2013
William and Libby experience personal tragedy. Masters decides to pair Austin with a stranger. Virginia struggles with her parenting due to her long hours. Ethan's relationship with Vivian takes the next step, whether he likes it or not.
Episode: 1x06 | Airdate: Nov 3, 2013
Bill and Libby vacation in Miami after losing the baby. Virginia attends a visiting doctor's speech and decides to investigate one of the claims on her own. Austin struggles with the reason for his non-performance in the study.
Episode: 1x07 | Airdate: Nov 10, 2013
Virginia and William ramp up their participation in the study. Libby bypasses William and pressures Ethan to resume the treatments. Austin and Margaret ramp up their tryst leading to differing expectations. Ethan decides to commit to Vivian.
Episode: 1x08 | Airdate: Nov 17, 2013
Virginia resumes pursuit of her undergraduate degree. Masters takes Virginia's suggestion and enlists the aid of a technician to construct a working camera to film the intimate workings during sexual intimacy.
Episode: 1x09 | Airdate: Nov 24, 2013
Virginia and Dr. Masters move on to filming involuntary reactions during the study, with Jane as usual being the first subject. Ethan reveals information about his heritage that threatens their relationship.
Episode: 1x10 | Airdate: Dec 1, 2013
A former study participant comes forward with news of her pregnancy. Ethan learns he has been effectively fired, but not for the reason he thought.
Episode: 1x11 | Airdate: Dec 8, 2013
Masters and Libby compile study information for hospital-wide presentation; DePaul and Johnson travel to a medical convention; Virginia's ex returns finds Ethan playing father to his children.
Episode: 1x12 | Airdate: Dec 15, 2013
Dr. Masters' big day is at hand after 12 months of studies. Without Virginia as a voice of moderation will Bill's pitch hit the mark? Margaret Scully is confronted with her husbands homosexuality and investigates what is involved with his 'treatment'. Dr. Austin Langham has a job offer from L.A and the climax to the episode sees Virginia Johnson reading the notes from Dr. William Masters presentation at home in the rain, to hear a knock at the door.
Season 2
Episode: 2x01 | Airdate: Jul 13, 2014
Following Bill's declaration in season 1 finale, Bill and Virginia resume their professional and personal relationship - both asserting it is to further the cause of their work. Virginia breaks the news to Ethan and Bill tries to be there for Libby and their new baby but finds it hard. Bill is struggling with getting his career back on track and Virginia is still working for Dr. DePaul but hungers for more. Scully is determined to succeed in his "therapy", but Margaret will bear no more illusions in her life.
Episode: 2x02 | Airdate: Jul 20, 2014
Masters begins a new job at Memorial Hospital - under Betty's terms - only to find his boss insisting he leave Virginia behind in favor of a handpicked secretary. Johnson, meanwhile, still alienated at Maternity, is torn between pressing Masters to rehire her and staying by DePaul's side as her condition worsens.
Episode: 2x03 | Airdate: Jul 27, 2014
Virginia unearths Masters' troubled childhood during a secret rendezvous.
Episode: 2x04 | Airdate: Aug 3, 2014
Johnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new post; and Betty tries to conceal her infertility from Gene, over Masters' objections.
Episode: 2x05 | Airdate: Aug 10, 2014
The study costs Masters his obstetrics and gynaecology practice. Johnson struggles with DePaul.
Episode: 2x06 | Airdate: Aug 17, 2014
After Hendricks bans Masters from using black participants in his study, Masters contacts a journalist to promote his efforts, using the debunking of sexual stereotypes as the lure. Johnson is forced to accept DePaul's choice to end her chemotherapy treatments. Gene uncovers the truth about Betty and Helen's relationship. Libby fires Coral after discovering she lied about Robert.
Episode: 2x07 | Airdate: Aug 24, 2014
In the wake of Masters' discovery that Johnson has continued to have romantic relationships with other men, he becomes impotent without her knowledge and cuts off their sexual work together. He tries to keep his new clinic solvent over the course of three years by borrowing against his house, offering medical services to the hotel - and finally accepting money from his mother.
Episode: 2x08 | Airdate: Aug 31, 2014
Johnson attempts to treat a woman on her own. Libby witnesses a hate crime.
Episode: 2x09 | Airdate: Sep 7, 2014
Virginia continues to impersonate a patient's case history in order to glean advice from a psychiatrist. Betty and Masters' attempt to remedy Lester's impotence by hiring a prostitute rattles him even further. Libby gets the third degree when she offers her eyewitness testimony regarding the beaten man. And Barbara Sanders wrestles with an unsettling diagnosis that exposes a chain of secrets and causes Masters and Johnson to clash over their treatment strategy.
Episode: 2x10 | Airdate: Sep 14, 2014
Masters learns of a rival study and calls in a public relations expert to help brand his work with Johnson. Virginia, having finally learned of Masters' sexual difficulties, is invigorated by the prospect of finding a cure. Determined to prove her worth to Robert, Libby canvases a tenement for a rent strike. Plus, Langham is stunned when Flo informs him that he has to have sex with her in order to keep his job. And Barbara and Lester connect over their shared sexual dysfunctions.
Episode: 2x11 | Airdate: Sep 21, 2014
A television crew arrives at the clinic to document Masters and Johnson's work treating sexual dysfunction. Masters considers the publicity premature, and himself unsuitable as a television presence. Virginia deals with the fallout of having prioritized her work over her parenting when George argues to take their children on a trip with his new wife. Plus, Libby finds in Robert an appreciation for what she has to offer. And Langham realizes there's no way out of his sexual contract with Flo.
Episode: 2x12 | Airdate: Sep 28, 2014
Masters and Johnson feel ready to cure sexual dysfunction.
Season 3
Episode: 3x01 | Airdate: Jul 12, 2015
Season 3 begins with Masters and Johnson facing the press for the first time as they prepare to publish their study. As they do so, they recall last year's summer vacation when Bill was finishing work on their book, Virginia was facing parenting struggles, and Libby was pulling herself out from beneath a deep depression.
Episode: 3x02 | Airdate: Jul 19, 2015
Masters takes on a high-profile patient; Virginia and Libby come to terms.
Episode: 3x03 | Airdate: Jul 26, 2015
Masters and Johnson try to capitalize on their growing fame.
Episode: 3x04 | Airdate: Aug 2, 2015
Masters tries to convince Johnson to rededicate herself to the study and to him; a familiar face returns to the clinic for help; Libby attempts to help Paul and Joy repair their shattered lives; Johnson fails to notice that Tessa is trying to make sense of her home life and the events at the homecoming dance.
Episode: 3x05 | Airdate: Aug 9, 2015
Johnson's parents visit and insert themselves in the Johnson women's lives; Libby and Masters learn that Johnny has been bullied and try to fix the problem; Johnson finds unexpected excitement in the scent study; a promising fertility patient is found.
Episode: 3x06 | Airdate: Aug 16, 2015
Masters and Johnson take on a celebrity couple who are looking to reinvigorate their sex life; Tessa comes to better understand her mother; Libby furthers her involvement in Joy's life but it comes with consequences that extend to Paul.
Episode: 3x07 | Airdate: Aug 23, 2015
Masters and Johnson are interviewed when they take on an exotic new patient.
Episode: 3x08 | Airdate: Aug 30, 2015
Johnson jets away with Dan Logan; Masters begins his surrogacy program.
Episode: 3x09 | Airdate: Sep 6, 2015
Masters continues his surrogacy program, which is now under Johnson's critical eye.
Episode: 3x10 | Airdate: Sep 13, 2015
Johnson objects to Masters' program, due to missteps in protocol.
Episode: 3x11 | Airdate: Sep 20, 2015
Agendas collide as Masters, Johnson, Logan and his wife meet for dinner.
Episode: 3x12 | Airdate: Sep 27, 2015
Season 3 ends with Masters and Johnson discovering that all of their hard work is now in jeopardy.
Season 4
Episode: 4x01 | Airdate: Sep 11, 2016
In the wake of their fallout, Masters and Johnson search for purpose in a world without one another and look to work as their personal lives crash down around them. Libby finds herself alone for the first time since her marriage and discovers some unexpected allies.
Episode: 4x02 | Airdate: Sep 18, 2016
Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and Virginia.
Episode: 4x03 | Airdate: Sep 25, 2016
Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single woman of the sexual revolution.
Episode: 4x04 | Airdate: Oct 2, 2016
Johnson, Masters, Libby and Keller wind up together at a party thrown by Art and Nancy. Pairings and perspectives shift as the night wears on, until the light of day exposes the consequences of the evening.
Episode: 4x05 | Airdate: Oct 9, 2016
Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean for him, Johnson and the practice.
Episode: 4x06 | Airdate: Oct 16, 2016
Johnson looks to get her relationship with Masters back on track while Masters does his best to find satisfaction elsewhere. Betty and Helen ready themselves for a new addition; Art and Nancy discuss the consequences of their party.
Episode: 4x07 | Airdate: Oct 23, 2016
Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights to Helen's baby.
Episode: 4x08 | Airdate: Oct 30, 2016
Masters and Johnson go on the road and pose as a couple to investigate practices at a competing clinic. While Bill and Virginia are away, Art, Nancy and Langham take advantage of their absence to further their own agendas.
Episode: 4x09 | Airdate: Nov 6, 2016
Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.
Episode: 4x10 | Airdate: Nov 13, 2016
Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace in one another.