Ramiro "Lalo" Padilla (played by Juan Gil Navarro) is the director of the media company "High Five", editor of the famous magazine Don, and has many women around him. Romina (played by Marcela Kloosterboer), who is in love with Lalo, decides to punish his lack of commitment to her. She hires a witch to cast a spell on him, which turns him into a very beautiful woman, as Romina wanted him to know what it is like for a woman who is being harassed.
Lalo (now played by Carla Peterson) awakes as a woman, in a state of utter confusion. However, Lalo's friend Graciela ("Grace") Neira (played by Muriel Santa Ana) believes what happened as she heard Romina's phone call to Lalo's home saying what she did. As it seems unlikely anyone else will believe that Ramiro has been magically transformed, so Ramiro assumes a new identity: Dolores "Lola" Padilla, cousin of Lalo. Lalo "had to make an urgent trip to Germany because his father became ill", and has appointed Lola to take his place. While trying to find a way to change back, there are a whole new set of challenges to face that Lalo didn't have to experience before, both within and outside the workplace.