Camaleones is the story of Valentina and Sebastián, who are both skilled thieves. They are united when a man they call "El Amo" forces them to commit crimes in order to protect their loved ones, who are in jail. El Amo wants to outwit Augusto Ponce de León, a corrupt police chief who is in charge of the "Chameleon" case, which he has to solve if he wants to reach a position in politics and gain more and more power. Valentina and Sebastián pose as prefect and art history teacher, respectively, at San Bartolomé School, where Augusto and Francisca, his wife, are the directors and owners; it is there where their daughter Solange studies.
The school's gardener, Leónidas, is an undercover policeman who plans to put Augusto in jail for his crimes and the death of his son, since Augusto threw him off a building and made everyone believe that he had committed suicide. Leónidas develops friendships with Valentina, Sebastian, Solange and Ulises, and from the basement of the school he is planning revenge against Augusto for pretending to be something he is not. Ironically, all the main characters pretend to be someone else, hence the name Chameleons.
