Most Extreme Humans

Most Extreme Humans follows people from around the globe living with the world's rarest and most remarkable physical conditions. From a Filipino man whose hands have grown so large he wears wristwatches as rings, to Brazil, where the world's smallest married couple have a combined height under six feet, to a 19-year-old in India living with the ultra-rare condition known as "werewolf syndrome." This series examines what everyday life looks like when the world is not built with your body in mind.

Show Info

Network: United States TLC (2026 - now)
Schedule: Wednesdays at 21:00 (60 min)
Status: Running
Show Type: Reality
Genres: Medical
Episodes ordered: 10 episodes

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Next Episode

Face to Face

Episode 1x05; Jul 8, 2026

Milagros lives with tumors so heavy that her face droops down to her torso; after hiding away, a health scare is forcing her out into the world; twenty-one-year old Lizzie is preparing to live independently even after tumors have grown over her eyes.

Previous Episodes

Episode NameAirdateTrailer
1x04: Peaks and ValleysJul 1, 2026
1x03: Upside Down with a TwistJun 24, 2026
1x02: Ugliest ManJun 17, 2026
View full episode list »
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