Most Extreme Humans

Most Extreme Humans follows people from around the globe living with the world's rarest and most remarkable physical conditions. From a Filipino man whose hands have grown so large he wears wristwatches as rings, to Brazil, where the world's smallest married couple have a combined height under six feet, to a 19-year-old in India living with the ultra-rare condition known as "werewolf syndrome." This series examines what everyday life looks like when the world is not built with your body in mind.

Show Info

Network: United States TLC (2026 - now)
Schedule: Wednesdays at 21:00 (60 min)
Status: Running
Show Type: Reality
Genres: Medical
Episodes ordered: 10 episodes

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Next Episode

Skin in the Game

Episode 1x07; Jul 22, 2026

Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions. Mahfuza prepares for her first boxing match. Nelly fully supports her friend but worries that the high risks may outweigh the rewards.

Previous Episodes

Episode NameAirdateTrailer
1x06: Hair Today, Gone Tomorrow?Jul 15, 2026
1x05: Face to FaceJul 8, 2026
1x04: Peaks and ValleysJul 1, 2026
View full episode list »
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