Prescott was born in Washington, D.C., then adopted and raised in Hartsville, South Carolina. She is best known for role as Jacqui in Season 1 of the television series The Walking Dead, which premiered on AMC in 2010. Prescott a resident of Winston-Salem, North Carolina divides her time between that city and Los Angeles. Prescott was originally cast for just two episodes of the premiere season of The Walking Dead. However, her character, Jacqui was then written into the series cast of the season as well. Prescott reprises her role as Jacqui in Season 3 episode "Hounded", as one of the voices that speaks to Rick on the phone. Mostly recently, Prescott recurred as Cherry in Ray Donovan on Showtime. Prescott also appeared as a judge Delilah Nunes in the Criminal Minds: Suspect Behavior, which debuted on CBS in 2011. Additionally, Prescott appear as Felicite in the film, Bolden! (2011). She has also cast in a film produced by Harry Lennix, based on William Shakespeare's Henry IV, Pt. 1. On television she also guest-starred on Brothers & Sisters, Southland, Parks and Recreation and Revolution.