The bus takes Ms. Frizzle and the class deep inside Arnold's cousin Janet to learn why our genes makes us look, act and feel the way we do.
Guest Cast
Lily Tomlin
voices Professor Fizzle
Nathan Fillion
voices Axle ValveStuck
Martin Short
voices Tony Tennelli
Catherine O'Hara
voices Aunt Tennelli
Jay Baruchel
voices Dr. Tillage
Birva Pandya
voices Jyoti
Matthew Mintz
voices Ralphie
Mikaela Blake
voices KeeshaCast Appearances
Kate McKinnon
voices Ms. Fiona Frizzle
Leke Maceda-Rustecki
voices CarlosEpisode Discussion
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