Special Guest Stars Jon Cryer as Lex Luthor Cara Buono as Gemma Cooper / Gamemnae Meaghan Rath as Female Brainiac-5 Guest Stars Brenda Strong as Lillian Luthor Anjali Jay as Serena (Alternate Earth) Winsome Brown as Ayala (Alternate Earth) Rosemary Hochschild as Vita (Alternate Earth) Co Starring Keith Dallas as Al Crane Uncredited Jesse Rath as Alternate Earth Brainy #1 Jesse Rath as Alternate Earth Brainy #3 Jesse Rath as Alternate Earth Brainy #4 Keith Dallas as Al (Alternate Earth)