Jesse Lee Soffer was born in Ossining, New York, to Jill Hindes (née Bruning) and Stan Soffer. His father died in 1993, when he was nine years old. Soffer spent part of his childhood in Tarrytown, New York, and later moved to Newtown, Connecticut, at age 10. Soffer boarded at The Gunnery, graduating in 2003. He played soccer in school and was named to the all-star team (prep school category) during his senior season. He took classes at New York University (NYU).
Soffer is known for portraying Will Munson on the CBS soap opera As the World Turns, and received three Emmy nominations for his work on the show. From 2014 to 2022, he starred as Jay Halstead on the NBC drama Chicago P.D. and guest-starred on its crossover episodes with Chicago Med and Chicago Fire, as part of the main cast. He is also known for his role as Bobby Brady in the comedy The Brady Bunch Movie and its sequel A Very Brady Sequel. From 2024 to present, Jesse Lee Soffer plays Wesley "Wes" Mitchell, the new International Fly Team leader on the fourth season of CBS drama FBI: International, after the departure of Luke Kleintank who played Scott Forester.
