Jesse Spencer was born in Melbourne, Victoria, Australia, as Jesse Gordon Spencer. He is an actor known for House (2004), Uptown Girls (2003), and Chicago Fire (2012). He married Kali Woodruff on June 27, 2020. He has three siblings who are all doctors,
He was in the Australian Boys Choir. He has played the violin since the age of 10 and also plays the guitar, the bass, and the piano.